Invention Grant
- Patent Title: Process for producing HMG-CoA reductase inhibitor
- Patent Title (中): 生产HMG-CoA还原酶抑制剂的方法
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Application No.: US12272448Application Date: 2008-11-17
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Publication No.: US07897370B2Publication Date: 2011-03-01
- Inventor: Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
- Applicant: Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
- Applicant Address: JP Tokyo
- Assignee: Kyowa Hakko Bio Co., Ltd.
- Current Assignee: Kyowa Hakko Bio Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP11-021707 19990129
- Main IPC: C12P17/06
- IPC: C12P17/06 ; C12P7/62 ; C12P7/40 ; C12P7/44 ; C12P7/42 ; C12P7/26 ; C12Q1/26 ; C07K14/00 ; C07H21/00 ; C12N1/21 ; C12N5/10 ; C12N15/00 ; C12P21/00
Abstract:
The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
Public/Granted literature
- US20090148916A1 PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR Public/Granted day:2009-06-11
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