Invention Grant
- Patent Title: Fungal cell wall synthesis gene
- Patent Title (中): 真菌细胞壁合成基因
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Application No.: US12060793Application Date: 2008-04-01
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Publication No.: US07897387B2Publication Date: 2011-03-01
- Inventor: Kappei Tsukahara , Katsura Hata , Koji Sagane , Kazutaka Nakamoto , Mamiko Tsuchiya , Naoaki Watanabe , Fuminori Ohba , Itaru Tsukada , Norihiro Ueda , Keigo Tanaka , Junko Kai
- Applicant: Kappei Tsukahara , Katsura Hata , Koji Sagane , Kazutaka Nakamoto , Mamiko Tsuchiya , Naoaki Watanabe , Fuminori Ohba , Itaru Tsukada , Norihiro Ueda , Keigo Tanaka , Junko Kai
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Townsend and Townsend and Crew LLP
- Priority: JP2000-206968 20000707; JP2000-316027 20001017
- Main IPC: C12N15/80
- IPC: C12N15/80 ; A61K36/06 ; A61K38/00
Abstract:
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
Public/Granted literature
- US20090117586A1 FUNGAL CELL WALL SYNTHESIS GENE Public/Granted day:2009-05-07
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