Invention Grant
- Patent Title: Conjugates of defined stoichiometry
- Patent Title (中): 定义化学计量的共轭物
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Application No.: US10381941Application Date: 2001-08-26
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Publication No.: US07897404B2Publication Date: 2011-03-01
- Inventor: Eva Hoess , Herbert Andres , Frederic Donie , Rudolf Vogel , Hans-Peter Josel , Rupert Hermann , Herbert Von Der Eltz
- Applicant: Eva Hoess , Herbert Andres , Frederic Donie , Rudolf Vogel , Hans-Peter Josel , Rupert Hermann , Herbert Von Der Eltz
- Applicant Address: US IN Indianapolis
- Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee Address: US IN Indianapolis
- Priority: DE10048417 20000929; EP01107491 20010329
- International Application: PCT/EP01/11101 WO 20010826
- International Announcement: WO02/27317 WO 20020404
- Main IPC: G01N30/02
- IPC: G01N30/02

Abstract:
The invention relates to a process for the production of a biomolecule-linker conjugate of uniform stochiometry. It especially relates to a conjugate consisting of a biomolecule of a molecular weight between 5 kD and 500 kD and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one biomolecule-linker product of uniform stoichiometry in a pre-selected amount.
Public/Granted literature
- US20040087501A1 Conjugates of defined stoichiometry Public/Granted day:2004-05-06
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