Invention Grant
- Patent Title: Use of HMGB fragments as anti-inflammatory agents
- Patent Title (中): 使用HMGB片段作为抗炎剂
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Application No.: US11901963Application Date: 2007-09-19
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Publication No.: US07897569B2Publication Date: 2011-03-01
- Inventor: Kevin J. Tracey , Huan Yang , Howland Shaw Warren, Jr. , Mitchell P. Fink
- Applicant: Kevin J. Tracey , Huan Yang , Howland Shaw Warren, Jr. , Mitchell P. Fink
- Applicant Address: US NY Manhasset US MA Boston US PA Pittsburgh
- Assignee: The Feinstein Institute for Medical Research,The General Hospital Corporation,University of Pittsburgh of the Commonwealth System of Higher Education
- Current Assignee: The Feinstein Institute for Medical Research,The General Hospital Corporation,University of Pittsburgh of the Commonwealth System of Higher Education
- Current Assignee Address: US NY Manhasset US MA Boston US PA Pittsburgh
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/00
Abstract:
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
Public/Granted literature
- US20080167234A1 Use of HMGB fragments as anti-inflammatory agents Public/Granted day:2008-07-10
Information query
