Invention Grant
US07897612B2 Substituted 1,8-naphthyridinecarboxamides for use as prolyl hydroxylase inhibitors 失效
用作脯氨酰羟化酶抑制剂的取代的1,8-萘啶甲酰胺

  • Patent Title: Substituted 1,8-naphthyridinecarboxamides for use as prolyl hydroxylase inhibitors
  • Patent Title (中): 用作脯氨酰羟化酶抑制剂的取代的1,8-萘啶甲酰胺
  • Application No.: US12281677
    Application Date: 2007-03-06
  • Publication No.: US07897612B2
    Publication Date: 2011-03-01
  • Inventor: Duke M. FitchMariela Colón
  • Applicant: Duke M. FitchMariela Colón
  • Applicant Address: US PA Philadelphia
  • Assignee: Glaxosmithkline, LLC
  • Current Assignee: Glaxosmithkline, LLC
  • Current Assignee Address: US PA Philadelphia
  • Agent Tony W. Peng; Edward R. Gimmi; Charles M. Kinzig
  • International Application: PCT/US2007/063359 WO 20070306
  • International Announcement: WO2007/103905 WO 20070913
  • Main IPC: A61K31/44
  • IPC: A61K31/44
Substituted 1,8-naphthyridinecarboxamides for use as prolyl hydroxylase inhibitors
Abstract:
The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
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