Invention Grant
- Patent Title: Crystalline polymorphs of clopidogrel
- Patent Title (中): 氯吡格雷的结晶多晶型物
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Application No.: US10571419Application Date: 2004-09-09
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Publication No.: US07897613B2Publication Date: 2011-03-01
- Inventor: Ramakrishnan Arul , Ajay Singh Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
- Applicant: Ramakrishnan Arul , Ajay Singh Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
- Applicant Address: GB Potters Bar, Hertfordshire
- Assignee: Generics [UK] Limited
- Current Assignee: Generics [UK] Limited
- Current Assignee Address: GB Potters Bar, Hertfordshire
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: GB0321256.0 20030911
- International Application: PCT/GB2004/003867 WO 20040909
- International Announcement: WO2005/026174 WO 20050324
- Main IPC: C07D495/04
- IPC: C07D495/04 ; A61K31/4365 ; A61P7/02

Abstract:
The present invention relates to novel crystalline forms of the platelet aggregation inhibitor (+)-(S)-methyl-2-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate, clopidogrel (1), in the form of hydrogen bromide salts, identified as polymorph forms 1, 2 and 3. The present invention further relates to processes for preparing such forms, pharmaceutical compositions comprising such forms, and uses for such forms and compositions. The pharmaceutical compositions may be used, in particular, for inhibiting platelet aggregation or for treating, preventing or managing thrombosis, atherothrombosis, an atherothrombotic event, ischaemic stroke, myocardial infarction, non-Q-wave myocardial infarction, atherosclerosis, peripheral arterial disease, or unstable angina. The present invention also relates to methods of treating said disorders. Formula (1).
Public/Granted literature
- US20070281964A1 Novel Crystalline Polymorphs of Clopidogrel Public/Granted day:2007-12-06
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