Invention Grant
US07897615B2 Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
有权
可用作丙二酰辅酶A脱羧酶抑制剂的氰酰胺化合物
- Patent Title: Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
- Patent Title (中): 可用作丙二酰辅酶A脱羧酶抑制剂的氰酰胺化合物
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Application No.: US11866266Application Date: 2007-10-02
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Publication No.: US07897615B2Publication Date: 2011-03-01
- Inventor: Mark D. Kafka , Mark E. Wilson , Anna Russell , Gary D. Lopaschuk , Jason R. Dyck
- Applicant: Mark D. Kafka , Mark E. Wilson , Anna Russell , Gary D. Lopaschuk , Jason R. Dyck
- Applicant Address: JP Tokyo
- Assignee: Chugai Sciyaku Kabushiki Kaisha
- Current Assignee: Chugai Sciyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/41 ; A61K31/425 ; A61K31/42
Abstract:
The present invention provides previous methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
Public/Granted literature
- US20080161358A1 Cyanoamide Compounds Useful as Malonyl-COA Decarboxylase Inhibitors Public/Granted day:2008-07-03
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