Invention Grant
- Patent Title: Heteroaryl derivatives as orexin receptor antagonists
- Patent Title (中): 杂芳基衍生物作为食欲蛋白受体拮抗剂
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Application No.: US12334559Application Date: 2008-12-15
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Publication No.: US07897627B2Publication Date: 2011-03-01
- Inventor: Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- Applicant: Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP07150294 20071221
- Main IPC: A61K31/517
- IPC: A61K31/517 ; A61K31/506 ; A61K31/501 ; A61K31/498 ; A61K31/4439 ; A61K31/427 ; A61K31/428 ; A61K31/4245 ; A61K31/423 ; C07D417/14 ; C07D417/12 ; C07D413/14 ; C07D413/12 ; C07D409/14 ; C07D405/14 ; C07D401/14 ; C07D403/12 ; C07D403/14
Abstract:
The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and are useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder and sleep disorders associated with neurological diseases.
Public/Granted literature
- US20090163485A1 HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS Public/Granted day:2009-06-25
Information query
IPC分类:
