Invention Grant
- Patent Title: TRAIL receptor-binding agents and uses of the same
- Patent Title (中): TRAIL受体结合剂及其用途
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Application No.: US12298001Application Date: 2007-04-29
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Publication No.: US07897730B2Publication Date: 2011-03-01
- Inventor: Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
- Applicant: Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
- Applicant Address: CN Beijing
- Assignee: Beijing Cotimes Biotech Ltd.
- Current Assignee: Beijing Cotimes Biotech Ltd.
- Current Assignee Address: CN Beijing
- Agency: Foley & Lardner LLP
- Priority: CN200610079301 20060430; CN200610109138 20070306
- International Application: PCT/CN2007/001453 WO 20070429
- International Announcement: WO2007/128321 WO 20071115
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K17/00 ; C07K17/14 ; C12P21/08 ; A61K39/395 ; A61K39/00
Abstract:
This invention relates generally to the preparation of TRAIL receptor-binding agents and uses of the same. In particular, the present invention relates to the preparation of anti-TRAIL receptor antibodies which recognize a common antigen determinant (i.e., epitope) shared by TRAIL-R1 and TRAIL-R2 receptors and their use for TRAIL receptor detection and modulation of TRAIL receptor-mediated function. The TRAIL receptor-binding agents are useful to induce apoptosis in human cancer cells. These targets may either express one or both TRAIL-R1 or TRAIL-R2. The invention provides for the use of the TRAIL receptor-binding agents of the invention in cancer therapy.
Public/Granted literature
- US20090136503A1 TRAIL RECEPTOR-BINDING AGENTS AND USES OF THE SAME Public/Granted day:2009-05-28
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