Invention Grant
US07897752B2 RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
有权
RNA干扰介导的使用短干扰核酸（siNA）的端粒酶基因表达的抑制
- Patent Title: RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
- Patent Title (中): RNA干扰介导的使用短干扰核酸（siNA）的端粒酶基因表达的抑制
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Application No.: US12170310Application Date: 2008-07-09
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Publication No.: US07897752B2Publication Date: 2011-03-01
- Inventor: James McSwiggen , Leonid Beigelman
- Applicant: James McSwiggen , Leonid Beigelman
- Applicant Address: US CA San Francisco
- Assignee: Sirna Therapeutics, Inc.
- Current Assignee: Sirna Therapeutics, Inc.
- Current Assignee Address: US CA San Francisco
- Agent Elaine C. Stracker
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; C12Q1/68
Abstract:
This invention relates to compounds, compositions, and methods useful for modulating telomerase gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of telomerase gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of telomerase genes, such as telomerase template RNA (TERC/TR), or a telomerase protein (TERT).
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