Invention Grant
- Patent Title: Acid addition salt of irinotecan
- Patent Title (中): 伊立替康的酸加成盐
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Application No.: US11576356Application Date: 2005-09-29
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Publication No.: US07897772B2Publication Date: 2011-03-01
- Inventor: Hideaki Shimizu , Miyuki Uchida , Seigo Sawada , Norimasa Kaneda , Tsuneo Matsumoto
- Applicant: Hideaki Shimizu , Miyuki Uchida , Seigo Sawada , Norimasa Kaneda , Tsuneo Matsumoto
- Applicant Address: JP Tokyo
- Assignee: Kabushiki Kaisha Yakult Honsha
- Current Assignee: Kabushiki Kaisha Yakult Honsha
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2004-289622 20041001
- International Application: PCT/JP2005/017999 WO 20050929
- International Announcement: WO2006/038526 WO 20060413
- Main IPC: C07D401/02
- IPC: C07D401/02
Abstract:
The present invention is directed to an irinotecan acid addition salt which is formed through addition of an acid selected from the group consisting of sulfuric acid, nitric acid, phosphoric acid, methanesulfonic acid, citric acid, maleic acid, and succinic acid to irinotecan, to a method for producing the salt, and to a pharmaceutical composition containing the salt. The addition salt requires no heating process during drug preparation and provides an aqueous drug product in which the salt is stably dissolved.
Public/Granted literature
- US20070299099A1 Acid Addition Salt of Irinotecan Public/Granted day:2007-12-27
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