Invention Grant
US07897777B2 Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate
有权
D，L-（±） - 甲基哌啶酯的对映异构体拆分方法
- Patent Title: Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate
- Patent Title (中): D，L-（±） - 甲基哌啶酯的对映异构体拆分方法
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Application No.: US11650278Application Date: 2007-01-05
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Publication No.: US07897777B2Publication Date: 2011-03-01
- Inventor: Alexei Kalinin , Guofang Qiu , Thomas J. Marren , James E. Aldred, Jr. , Yu Ji
- Applicant: Alexei Kalinin , Guofang Qiu , Thomas J. Marren , James E. Aldred, Jr. , Yu Ji
- Applicant Address: US MO Springfield
- Assignee: Archimica, Inc.
- Current Assignee: Archimica, Inc.
- Current Assignee Address: US MO Springfield
- Agency: ProPat, L.L.C.
- Main IPC: C07D211/34
- IPC: C07D211/34
Abstract:
A process for preparing the d-threo isomer of methylphenidate hydrochloride which includes (i) resolving a racemic mixture of racemic threo-methylphenidate hydrochloride with a less than stoichiometric amount of tertiary amine base to obtain a methylphenidate-chiral acid salt, (ii) basifying the methylphenidate-chiral acid salt to obtain methylphenidate free base, and (iii) converting the methylphenidate free base into d-threo-methylphenidate hydrochloride.
Public/Granted literature
- US20080167470A1 Process of enantiomeric resolution of D,L-(+_)-threo-methylphenidate Public/Granted day:2008-07-10
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