Invention Grant
- Patent Title: Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region
- Patent Title (中): 人突变热点区域内大鼠腺瘤性息肉病基因突变
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Application No.: US11591653Application Date: 2006-11-01
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Publication No.: US07897834B2Publication Date: 2011-03-01
- Inventor: William F. Dove , Michael N. Gould , Lawrence N. Kwong , James M. Amos-Landgraf , Jill D. Haag
- Applicant: William F. Dove , Michael N. Gould , Lawrence N. Kwong , James M. Amos-Landgraf , Jill D. Haag
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- Main IPC: A01K67/00
- IPC: A01K67/00 ; C07H21/04
Abstract:
A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the knockout rat are provided. Also provided is the offspring or progeny of that rat. In addition, methods of using these rats are provided, including methods for screening a carcinogen or a promoter of carcinogenesis, and methods for screening preventive and inhibitory agents of carcinogenesis.
Public/Granted literature
- US20070143867A1 Mutation in the rat Adenomatous Polyposis Coli gene within the human mutation hotspot region Public/Granted day:2007-06-21
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