Managing Message Signaled Interrupts (MSIs). For example, a method of managing MSI requests in a computing system may include receiving a plurality of MSI requests from one or more components of the computing system; directing data of the plurality of MSI requests to be stored sequentially, according to a First In First Out (FIFO) order, in successive entries of a FIFO structure defined in a main memory of the computing system; and directing a processor of the computing system to retrieve data of one or more of the plurality of MSI requests from the FIFO structure to be processed according to the FIFO order. Other embodiments are described and claimed.