The present invention provides a multi-piece solid golf ball, of which flight distance is improved by accomplishing high launch angle and low spin amount, when hit by golfers, who swing a golf club at low head speed, using a middle iron club to a driver. The present invention relates to multi-piece solid golf ball comprising a center, an intermediate layer formed on the center and a cover covering the intermediate layer, wherein the intermediate layer is formed from only one material having a flexural stiffness of 400 to 5,000 MPa.