Invention Grant
- Patent Title: Hedgehog antibodies
- Patent Title (中): 刺猬抗体
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Application No.: US11197721Application Date: 2005-08-03
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Publication No.: US07901686B2Publication Date: 2011-03-08
- Inventor: Clifford Tabin , Valeria Marigo , Philip W. Ingham , Andrew P. McMahon
- Applicant: Clifford Tabin , Valeria Marigo , Philip W. Ingham , Andrew P. McMahon
- Applicant Address: US MA Cambridge GB London
- Assignee: President and Fellows of Harvard College,Imperial Cancer Research Technology Ltd.
- Current Assignee: President and Fellows of Harvard College,Imperial Cancer Research Technology Ltd.
- Current Assignee Address: US MA Cambridge GB London
- Agency: Ropes & Gray LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/00 ; C07K14/00
Abstract:
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
Public/Granted literature
- US20050282231A1 Screening assays for hedgehog agonists and antagonists Public/Granted day:2005-12-22
Information query
