Invention Grant
US07901687B2 Antibodies for the detection of Bacillus anthracis and vaccine against B. anthracis infections
失效
用于检测炭疽芽孢杆菌和针对炭疽杆菌感染的疫苗的抗体
- Patent Title: Antibodies for the detection of Bacillus anthracis and vaccine against B. anthracis infections
- Patent Title (中): 用于检测炭疽芽孢杆菌和针对炭疽杆菌感染的疫苗的抗体
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Application No.: US12226728Application Date: 2007-04-27
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Publication No.: US07901687B2Publication Date: 2011-03-08
- Inventor: Daniel B. Werz , Peter H. Seeberger , Marco Tamborrini , Gerd Pluschke
- Applicant: Daniel B. Werz , Peter H. Seeberger , Marco Tamborrini , Gerd Pluschke
- Applicant Address: CH Zurich CH Basel
- Assignee: Eth Zurich,Schweizerisches Tropeninstitut
- Current Assignee: Eth Zurich,Schweizerisches Tropeninstitut
- Current Assignee Address: CH Zurich CH Basel
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: EP06116359 20060629
- International Application: PCT/EP2007/054137 WO 20070427
- International Announcement: WO2007/125089 WO 20071108
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38 ; A61K39/40 ; A61K39/395 ; A61K45/00 ; A61K47/00

Abstract:
The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.
Public/Granted literature
- US20090155299A1 Antibodies for the Detection of Bacillus Anthracis and Vaccine Against B. Anthracis Infections Public/Granted day:2009-06-18
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