Invention Grant
- Patent Title: Nontypeable Haemophilus influenzae virulence factors
- Patent Title (中): 不可流行的流感嗜血杆菌毒力因子
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Application No.: US12761074Application Date: 2010-04-15
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Publication No.: US07901692B2Publication Date: 2011-03-08
- Inventor: Lauren O. Bakaletz , Robert S. Munson, Jr.
- Applicant: Lauren O. Bakaletz , Robert S. Munson, Jr.
- Applicant Address: US OH Columbus
- Assignee: Nationalwide Children's Hospital, Inc.
- Current Assignee: Nationalwide Children's Hospital, Inc.
- Current Assignee Address: US OH Columbus
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K39/102
- IPC: A61K39/102
Abstract:
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.
Public/Granted literature
- US20100196382A1 Nontypeable Haemophilus Influenzae Virulence Factors Public/Granted day:2010-08-05
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