Invention Grant
- Patent Title: NPC1L1 (NPC3) and methods of identifying ligands thereof
- Patent Title (中): NPC1L1（NPC3）及鉴定其配体的方法
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Application No.: US10586310Application Date: 2005-01-14
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Publication No.: US07901893B2Publication Date: 2011-03-08
- Inventor: Maria Margarita Garcia-Calvo
- Applicant: Maria Margarita Garcia-Calvo
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Carol S. Quagliato; Catherine D. Fitch
- International Application: PCT/US2005/001469 WO 20050114
- International Announcement: WO2005/069900 WO 20050804
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/532 ; C07D205/08
Abstract:
The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations. Compounds that bind to NPCILI can be used for inhibiting intestinal cholesterol absorption in a subject.
Public/Granted literature
- US20100009461A1 Npcil1 (Npc3) And Methods Of Identifying Ligands Thereof Public/Granted day:2010-01-14
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