Invention Grant
- Patent Title: Chimaeric phages
- Patent Title (中): 杂种噬菌体
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Application No.: US11977954Application Date: 2007-10-26
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Publication No.: US07901919B2Publication Date: 2011-03-08
- Inventor: Erwin Houtzager , Ton Logtenberg , Cornelis Adriaan De Kruif
- Applicant: Erwin Houtzager , Ton Logtenberg , Cornelis Adriaan De Kruif
- Applicant Address: NL Leiden
- Assignee: Crucell Holland B.V.
- Current Assignee: Crucell Holland B.V.
- Current Assignee Address: NL Leiden
- Agency: TraskBritt, P.C.
- Priority: EP01202304 20010615
- Main IPC: C12N7/00
- IPC: C12N7/00 ; C12N7/01 ; C12P21/06

Abstract:
The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, wherein the mutant form is impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages.
Public/Granted literature
- US20090017521A1 Chimaeric phages Public/Granted day:2009-01-15
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