Invention Grant
US07901936B2 Method for stimulating self-renewal of neural stem cells and enhancing neurogenesis
有权
刺激神经干细胞自我更新和增强神经发生的方法
- Patent Title: Method for stimulating self-renewal of neural stem cells and enhancing neurogenesis
- Patent Title (中): 刺激神经干细胞自我更新和增强神经发生的方法
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Application No.: US11095019Application Date: 2005-03-31
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Publication No.: US07901936B2Publication Date: 2011-03-08
- Inventor: Sally Temple , Qin Shen , Susan K. Goderie
- Applicant: Sally Temple , Qin Shen , Susan K. Goderie
- Applicant Address: US NY Albany
- Assignee: Albany Medical College
- Current Assignee: Albany Medical College
- Current Assignee Address: US NY Albany
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Agent Kathy Smith Dias
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12N5/793 ; C12N5/797
Abstract:
The present invention provides a mechanism for obtaining an almost unlimited source of stem cells. A method for the expansion of a population of stem cells that retain their developmental capacity comprises co-culture of a stem cell population with a trophic support, for example, endothelial cells or conditioned medium derived from endothelial cell culture. The method also provides a method for enhancing neurogenesis when neural stem cells are co-cultured with the endothelial cell-derived trophic support to retain their neurogenic potential.
Public/Granted literature
- US20050277189A1 Method for stimulating self-renewal of neural stem cells and enhancing neurogenesis Public/Granted day:2005-12-15
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