Invention Grant
- Patent Title: Use of AIM3 acting as a tumor suppressor
- Patent Title (中): 使用AIM3作为肿瘤抑制因子
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Application No.: US11902641Application Date: 2007-09-24
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Publication No.: US07902165B2Publication Date: 2011-03-08
- Inventor: Sunghoon Kim
- Applicant: Sunghoon Kim
- Applicant Address: KR Seoul
- Assignee: Seoul National University Industry Foundation
- Current Assignee: Seoul National University Industry Foundation
- Current Assignee Address: KR Seoul
- Agency: Buchanan Ingersoll & Rooney PC
- Priority: KR10-2004-0029205 20040427
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.
Public/Granted literature
- US20080200382A1 Novel use of AIM3 acting as a tumor suppressor Public/Granted day:2008-08-21
Information query
