Invention Grant
US07902167B2 Compounds and methods for down-regulating Wrap53 protein by RNA interference
失效
通过RNA干扰下调Wrap53蛋白的化合物和方法
- Patent Title: Compounds and methods for down-regulating Wrap53 protein by RNA interference
- Patent Title (中): 通过RNA干扰下调Wrap53蛋白的化合物和方法
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Application No.: US12444043Application Date: 2007-10-01
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Publication No.: US07902167B2Publication Date: 2011-03-08
- Inventor: Marianne Farnebo , Salah Mahmoudi , Klas Wiman
- Applicant: Marianne Farnebo , Salah Mahmoudi , Klas Wiman
- Applicant Address: SE Stockholm
- Assignee: Aprea AB
- Current Assignee: Aprea AB
- Current Assignee Address: SE Stockholm
- Agency: Browdy and Neimark, PLLC
- Priority: SE0602041 20061002
- International Application: PCT/SE2007/050692 WO 20071001
- International Announcement: WO2008/041933 WO 20080410
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04
Abstract:
A small nucleic acid molecule that down-regulates expression of Wrap53 gene via RNA interference (RNAi), wherein at least one strand of said small nucleic acid molecule is about 15 to about 30 nucleotides in length; and wherein at least one strand of said small nucleic acid molecule comprises a nucleotide sequence having sufficient complementarity to an RNA of said Wrap53 gene for the small nucleic acid molecule to direct cleavage of said RNA via RNA interference, for use as a medicament.
Public/Granted literature
- US20100113558A1 COMPOUNDS AND METHODS Public/Granted day:2010-05-06
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