Invention Grant
US07902168B2 Compositions and methods for inhibiting expression of Nav1.8 gene
有权
用于抑制Nav1.8基因表达的组合物和方法
- Patent Title: Compositions and methods for inhibiting expression of Nav1.8 gene
- Patent Title (中): 用于抑制Nav1.8基因表达的组合物和方法
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Application No.: US12487605Application Date: 2009-06-18
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Publication No.: US07902168B2Publication Date: 2011-03-08
- Inventor: Dinah Wen-Yee Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
- Applicant: Dinah Wen-Yee Sah , Maria Frank-Kamenetsky , Anke Geick , Philipp Hadwiger , Ingo Roehl , Pamela Tan , Hans-Peter Vornlocher
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K31/70 ; C12N5/00
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.
Public/Granted literature
- US20090258934A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Nav1.8 GENE Public/Granted day:2009-10-15
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