Invention Grant
- Patent Title: Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient
- Patent Title (中): 吲哚衍生物，其制备方法和用于预防和治疗含有其作为活性成分的代谢紊乱的组合物
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Application No.: US12442930Application Date: 2007-09-27
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Publication No.: US07902190B2Publication Date: 2011-03-08
- Inventor: Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
- Applicant: Kyeong Lee , Hyun Sun Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
- Applicant Address: KR Daejeon-Si
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon-Si
- Agency: Greenlee Sullivan P.C.
- Priority: KR10-2006-0094138 20060927
- International Application: PCT/KR2007/004722 WO 20070927
- International Announcement: WO2008/039007 WO 20080403
- Main IPC: A61K31/535
- IPC: A61K31/535
Abstract:
Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
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