Invention Grant
- Patent Title: Isoxazolo-pyrazine derivatives
- Patent Title (中): 异恶唑并吡嗪衍生物
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Application No.: US12788338Application Date: 2010-05-27
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Publication No.: US07902201B2Publication Date: 2011-03-08
- Inventor: Bernd Buettelmann , Roland Jakob-Roetne , Henner Knust , Andrew Thomas
- Applicant: Bernd Buettelmann , Roland Jakob-Roetne , Henner Knust , Andrew Thomas
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP07122271 20071204
- Main IPC: A61K31/4965
- IPC: A61K31/4965
Abstract:
The invention relates to isoxazolo-pyrazine derivatives and their pharmaceutically acceptable salts having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, and pharmaceutical compositions containing them. The compounds of the present invention are inverse agonists of GABAAα5. The invention also relates to methods for enhancing cognition and for treating cognitive disorders like Alzheimer's disease.
Public/Granted literature
- US20100256154A1 ISOXAZOLO-PYRAZINE DERIVATIVES Public/Granted day:2010-10-07
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