Systems and methods for multi-band amplification. In an exemplary embodiment of the present invention, the multi-band amplification device has an uplink amplifier with a first port and a second port and a downlink amplifier with a first port and a second port. Furthermore, the multi-band amplification device has a first duplexer device in communication with the first port of the downlink amplifier and the second port of the uplink amplifier and a second duplexer device in communication with the first port of the uplink amplifier and the second port of the downlink amplifier. The first duplexer device is enabled to receive and transmit at least a downlink signal and an uplink signal of a first frequency band, a downlink signal and an uplink signal of a second frequency band, and a downlink signal and an uplink signal of a third frequency band. The second duplexer device is enabled to receive and transmit at least the downlink signal and the uplink signal of the first frequency band, the downlink signal and the uplink signal of the second frequency band, and the downlink signal and the uplink signal of the third frequency band.