A wireless mesh network routes messages between a host computer and a plurality of field devices. The mesh network is synchronized to a global regular active schedule that defines active periods when messages can be transmitted or received by nodes of the network, and inactive periods when messages cannot be transmitted or received. Based upon messages to be sent by the host computer to selected field devices, the network is controlled to selectively maintain active those nodes required to route messages to the selected field devices. Those required nodes are maintained in an active state as long as communication with the selected field devices continues, while other nodes are allowed to return to a low power inactive state. When communication between the host computer and the selected field devices is no longer required, the entire network is allowed to enter the low power inactive state.