The invention interacts with subjects to query, challenge, and identify aspects and multidimensional influences providing access to, modulation and entrainment of, state-specific global bio-regulatory self-organizing controllers and evocable triggers. Modulating state-specific regulatory triggers may evoke optimized emergent self-organizing principles within a subject and support up-regulating “states of presence,” including newly emergent controllers of additional optimal regulation of bio-chemical expressions. A subject's “state” measures may include the status of a combination of multiple identified biological qualities. Provided are systems and methods supporting access to a subject's state controller functions, for various ailments, to empower shifting ones' biology from a symptomatic to an asymptomatic state and to optimal adaptive learning and readiness. Also enabled are investigation and access to capacities that control such state shifts so that they can be broadly challenged, expanded, and entrained for optimized global regulatory function in reversing a myriad of pathological symptoms, learning limitation, and adaptive dysregulations.