Methods, systems, and computer program products assess and manage work-related musculoskeletal injuries associated with one or more work sites. A method involves defining musculoskeletal injury categories and drawing relationships between the musculoskeletal injury categories by applying specialized medical knowledge. The relationships prevent informational disconnect between slightly disparate diagnoses between physicians who evaluate a same patient for the work-related musculoskeletal injury. The method also involves structuring storage of the relationships in a relational database, gathering for each work site, demographics and statistics on work-related musculoskeletal injuries associated with at least one of relatively high lost time or relatively high medical cost, and utilizing the relationships and the demographics to compile and retrieve data that facilitates prevention or improved resolution of the musculoskeletal injury.