A computer program product, apparatus, and method for processing a transport control channel program with chain linked branching in an I/O processing system are provided. The method includes receiving a command message at a control unit from an I/O subsystem to perform an I/O operation. The method further includes reading a chain linked flag in the command message indicating that a subsequent command message for the I/O operation follows the command message. The method also includes reading a serialization flag in the command message requesting that device status be returned to the I/O subsystem in order to select the subsequent command message. The method additionally includes executing one or more commands in the command message, and transmitting the device status to the I/O subsystem in response to executing the one or more commands in combination with the serialization flag.