Invention Grant
- Patent Title: Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
- Patent Title (中): 用于修饰释放活性成分的水性悬浮液形式的口服药物制剂
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Application No.: US10510643Application Date: 2003-04-07
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Publication No.: US07906145B2Publication Date: 2011-03-15
- Inventor: Catherine Castan , Florence Guimberteau , Rémi Meyrueix
- Applicant: Catherine Castan , Florence Guimberteau , Rémi Meyrueix
- Applicant Address: FR Venissieux
- Assignee: Flamel Technologies
- Current Assignee: Flamel Technologies
- Current Assignee Address: FR Venissieux
- Agency: Patton Boggs LLP
- Priority: FR0204409 20020409; FR0210847 20020902
- International Application: PCT/FR03/01096 WO 20030407
- International Announcement: WO03/084518 WO 20031016
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/16 ; A61K9/40

Abstract:
The invention concerns liquid pharmaceutical formulations, for oral delivery, with modified release of active principle(s) excluding amoxicillin and consisting of suspensions of coated particles of active principles (microcapsules). The microcapsules constituting the dispersed phase of the suspension are designed, according to the invention, to enable modified release of the active principle(s), in accordance with a profile which remains unaltered during the shelf life of the liquid suspension. Therefor, the invention consists in selecting a coating composition specific to the microcapsules consisting of at least four components enabling preservation of said microcapsules in water without altering their properties of modified release of the active principle, said liquid phase being furthermore saturated with active principle(s).
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