Invention Grant
US07906460B2 Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnatural” UDP- and TDP-nucleotide sugars
有权
核苷酸转移酶的活性位点工程和合成天然和“非天然”UDP-和TDP-核苷酸糖的一般酶法
- Patent Title: Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnatural” UDP- and TDP-nucleotide sugars
- Patent Title (中): 核苷酸转移酶的活性位点工程和合成天然和“非天然”UDP-和TDP-核苷酸糖的一般酶法
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Application No.: US11536208Application Date: 2006-09-28
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Publication No.: US07906460B2Publication Date: 2011-03-15
- Inventor: Jon Thorson , Dimitar B. Nikilov
- Applicant: Jon Thorson , Dimitar B. Nikilov
- Applicant Address: US NY New York
- Assignee: Sloan-Kettering Institute for Cancer
- Current Assignee: Sloan-Kettering Institute for Cancer
- Current Assignee Address: US NY New York
- Agency: Quarles & Brady, LLP
- Main IPC: C40B40/06
- IPC: C40B40/06 ; C12N9/10
Abstract:
The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars synthesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.
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