Invention Grant
US07906491B2 Compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs)
有权
用于调节由cAMP（Epacs）直接激活的交换蛋白的活性的化合物
- Patent Title: Compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs)
- Patent Title (中): 用于调节由cAMP（Epacs）直接激活的交换蛋白的活性的化合物
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Application No.: US10517564Application Date: 2003-06-10
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Publication No.: US07906491B2Publication Date: 2011-03-15
- Inventor: John De Koning , Anne Christensen , Frank Schwede , Hans Gottfired Genieser , Stein Doskeland , Johannes Bos
- Applicant: John De Koning , Anne Christensen , Frank Schwede , Hans Gottfired Genieser , Stein Doskeland , Johannes Bos
- Applicant Address: NL Utrecht
- Assignee: Univisitair Medisch Centrum Utrecht
- Current Assignee: Univisitair Medisch Centrum Utrecht
- Current Assignee Address: NL Utrecht
- Agency: Morgan, Lewis & Bockius LLP
- Agent Richard F. Trecartin
- Priority: EP02077219 20020607
- International Application: PCT/EP03/06120 WO 20030610
- International Announcement: WO03/104250 WO 20031218
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H19/213
Abstract:
The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the compounds of the invention are substituted deoxyadenosine-cyclic monosphosphates.The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of diseases like cancer, chronic inflammation, thrombosis and/or type-2 diabetes mellitus in humans and/or animals.
Public/Granted literature
- US20060100166A1 Compounds for modulating the activity of exchange proteins directly activated by camp (epacs) Public/Granted day:2006-05-11
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