Invention Grant
- Patent Title: Pyrrole derivatives with angiotensin II antagonist activity
- Patent Title (中): 具有血管紧张素II拮抗剂活性的吡咯衍生物
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Application No.: US11568362Application Date: 2005-04-27
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Publication No.: US07906501B2Publication Date: 2011-03-15
- Inventor: Francesco Makovec , Roberto Artusi , Antonio Giordani , Simona Zanzola , Lucio Claudio Rovati
- Applicant: Francesco Makovec , Roberto Artusi , Antonio Giordani , Simona Zanzola , Lucio Claudio Rovati
- Applicant Address: IT Milan
- Assignee: Rottapharm S.p.A.
- Current Assignee: Rottapharm S.p.A.
- Current Assignee Address: IT Milan
- Agency: Roylance, Abrams, Berdo & Goodman, L.L.P.
- Priority: ITTO04A0264 20040428
- International Application: PCT/EP2005/051911 WO 20050427
- International Announcement: WO2005/105789 WO 20051110
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D293/00 ; C07D257/04 ; C07D403/10 ; C07D295/04

Abstract:
Compounds which may be represented by the general formula (I) shown below and in which: R1 is a group independently selected from among: CHO, —COOH, —CH2OH R2 is hydrogen or a linear or branched C1-C6 alkyl group R3 is hydrogen or a halogen group selected from among Cl and Br R4 is a linear or branched C3-C5 alkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the AT1 receptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy.
Public/Granted literature
- US20070244170A1 Novel Pyrrole Derivatives with Angiotensin II Antagonist Activity Public/Granted day:2007-10-18
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