Invention Grant
US07906637B2 Compositions and methods for inducing or inhibiting activities of selected human cells
有权
用于诱导或抑制选定人细胞活性的组合物和方法
- Patent Title: Compositions and methods for inducing or inhibiting activities of selected human cells
- Patent Title (中): 用于诱导或抑制选定人细胞活性的组合物和方法
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Application No.: US12306031Application Date: 2007-06-20
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Publication No.: US07906637B2Publication Date: 2011-03-15
- Inventor: Philip M. Potter , Monika Weirdl , Matthew R. Redinbo
- Applicant: Philip M. Potter , Monika Weirdl , Matthew R. Redinbo
- Applicant Address: US TN Memphis US NC Chapel Hill
- Assignee: St. Jude Children's Research Hospital,The University of North Carolina at Chapel Hill
- Current Assignee: St. Jude Children's Research Hospital,The University of North Carolina at Chapel Hill
- Current Assignee Address: US TN Memphis US NC Chapel Hill
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2007/071640 WO 20070620
- International Announcement: WO2008/066964 WO 20080605
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N5/00 ; C12N5/02
Abstract:
Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
Public/Granted literature
- US20090275510A1 Compositions and Methods for Inducing or Inhibiting Activities of Selected Human Cells Public/Granted day:2009-11-05
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