Invention Grant
US07906638B2 Chimeric nucleic acids encoding polypeptides comprising CD70 and Fas ligand domains
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编码包含CD70和Fas配体结构域的多肽的嵌合核酸
- Patent Title: Chimeric nucleic acids encoding polypeptides comprising CD70 and Fas ligand domains
- Patent Title (中): 编码包含CD70和Fas配体结构域的多肽的嵌合核酸
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Application No.: US12371188Application Date: 2009-02-13
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Publication No.: US07906638B2Publication Date: 2011-03-15
- Inventor: Thomas J. Kipps , Sanjai Sharma , Mark Cantwell
- Applicant: Thomas J. Kipps , Sanjai Sharma , Mark Cantwell
- Applicant Address: US CA Oakland
- Assignee: Regents of the University of California
- Current Assignee: Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: DLA Piper LLP (US)
- Main IPC: C12N15/62
- IPC: C12N15/62 ; C12N15/12 ; C12N15/00 ; C12N15/63
Abstract:
This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.
Public/Granted literature
- US20100267129A1 CHIMERIC NUCLEIC ACIDS ENCODING POLYPEPTIDES COMPRISING DOMAINS OF TNF FAMILY LIGANDS Public/Granted day:2010-10-21
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