Invention Grant
US07906649B2 Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
有权
氨基环己烷作为二肽基肽酶-IV抑制剂治疗糖尿病
- Patent Title: Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
- Patent Title (中): 氨基环己烷作为二肽基肽酶-IV抑制剂治疗糖尿病
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Application No.: US11920038Application Date: 2006-05-19
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Publication No.: US07906649B2Publication Date: 2011-03-15
- Inventor: Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Ann E. Weber , Jason Cox
- Applicant: Tesfaye Biftu , Danqing Feng , Xiaoxia Qian , Ann E. Weber , Jason Cox
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; John C. Todaro
- International Application: PCT/US2006/019598 WO 20060519
- International Announcement: WO2006/127530 WO 20061130
- Main IPC: C07D513/02
- IPC: C07D513/02 ; C07D513/00 ; C07D498/00 ; C07D403/02 ; C07D487/02 ; C07D209/44 ; A61K31/425 ; A61K31/42 ; A61K31/415 ; A61K31/40
Abstract:
The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Public/Granted literature
- US20090105284A1 Aminocyclohexanes as Dipeptidyl Peptidase-IV for the Treatment or Prevention of Diabetes Public/Granted day:2009-04-23
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