Apparatus and methods for retention of computer expansion cards and/or card bay covers inside a card bay of an information handling system chassis, and that may include an expansion card retaining apparatus that includes a pivotable first end configured to attachably rotate relative to a securing surface of the information handling system chassis, a latching second end configured to releasably lock the expansion card retaining apparatus in a locking position that prevents rotation of the expansion card retaining apparatus about the pivotable first end, at least one resiliently deformable coupling section extending between the pivotable first end and the latching second end to maintain the latching second end in the locking position, and a retention section extending between the at least one coupling section and the pivotable first end.