A system identifies multiple medical conditions, observations, and laboratory test results using active sensors and predetermined rules to identify infected patients. An infection control and workflow management system includes a repository of worker information identifying healthcare workers for performing infection control tasks as well as worker associated communication data for use in informing healthcare workers of infection control tasks to be performed. A detection processor automatically detects infection in patients from multiple different sources including from at least one of, (a) a medical record evaluated upon admission of a patient to a hospital and (b) a laboratory test result. A workflow processor uses the worker information for automatically communicating a message to inform a healthcare worker of a task to be performed to initiate infection control tasks using communication data in response to detection of an infected patient.