A pharmaceutical waste disposal device comprises an upper portion adapted for receiving pharmaceutical waste and a lower portion adapted for collecting the pharmaceutical waste, the lower portion being selectively and removably engagable with the upper portion. The upper portion includes a housing surrounding an internal rotating wheel and a lid slideably engaged with the housing. Additionally, the rotating wheel includes collection areas adapted for collecting pharmaceutical waste placed in the upper portion. The lid includes a lower pivoting flap adapted for contacting and rotating the wheel upon closing the lid to transfer the pharmaceutical waste to the lower portion. Further, the rotating wheel is sized and positioned within the housing in a manner to substantially prevent access to the pharmaceutical waste collected in the lower portion.