A computer dock station includes a bracket covered with a cover member and having a fence at one side and upright pivot pins on the inside, and a locking mechanism, which includes a motive member, two follower members pivoted to the two opposite ends of the motive member and respectively coupled with the respective sliding slot to the upright pivot pins, two clamps respectively mounted on the follower members outside the bracket, and a screw rod threaded through the motive member and pivoted to the bracket and rotatable to move the motive member and to further turn the follower members about the respective upright pivot pins for adjusting the position of the clamps.