An unlock transmission mechanism for escape doors is disclosed, including a base, a transmission member, a first drive unit and a second drive unit, wherein the transmission member, the first drive unit and second drive unit are all disposed on the base, and the transmission member is actuated to move relative to the first drive unit and the second drive unit, respectively. In the case that the unlock transmission mechanism is to be installed in an escape door that has a different installation orientation, the transmission member and the first drive unit provided therein have the characteristics of multi-directional changeability, thereby enabling flexible installation of the escape door lock and eliminating the necessity to replace an existing door handle mechanism as encountered in the prior art.