Invention Grant
- Patent Title: Method for drug delivery to ocular tissue using microneedle
- Patent Title (中): 使用微针将药物递送至眼组织的方法
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Application No.: US11743535Application Date: 2007-05-02
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Publication No.: US07918814B2Publication Date: 2011-04-05
- Inventor: Mark R. Prausnitz , Ninghao Jiang , Henry F. Edelhauser
- Applicant: Mark R. Prausnitz , Ninghao Jiang , Henry F. Edelhauser
- Applicant Address: US GA Atlanta US GA Atlanta
- Assignee: Georgia Tech Research Corporation,Emory University
- Current Assignee: Georgia Tech Research Corporation,Emory University
- Current Assignee Address: US GA Atlanta US GA Atlanta
- Agency: Sutherland Asbill & Brennan LLP
- Main IPC: A61N1/30
- IPC: A61N1/30

Abstract:
Methods and devices are provided for administering a drug to a patient's eye. The methods include (a) inserting a hollow microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma; and (b) infusing a fluid drug formulation through the microneedle and into the sclera or cornea. It further may include partially retracting the microneedle before infusion to enhance delivery. Alternatively, the methods may include (a) inserting a solid microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma, wherein the solid microneedle comprises a first quantity of a drug formulation and inserting causes the solid microneedle to form a pocket in the sclera or corneal stroma; and (b) releasing the drug formulation into the pocket to form a drug depot, whereby a drug is released from the depot. The methods and devices may include an array of multiple microneedles.
Public/Granted literature
- US20070260201A1 METHOD FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE Public/Granted day:2007-11-08
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