The portable dialysis machine may include an enclosure having a removable base. There may be a front panel having associated therewith multiple external connectors, smart function keys, a touch panel element and a voice activated sensor. The front panel may be in communication with an electronic circuit element having a controller in communication therewith. There may be a blood flow element and a hydraulic flow element. A water reservoir and power supply may be included. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.