Invention Grant
US07919076B2 PH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy
有权
用于靶向治疗的蒽环类抗癌药物的PH敏感性聚合物缀合物
- Patent Title: PH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy
- Patent Title (中): 用于靶向治疗的蒽环类抗癌药物的PH敏感性聚合物缀合物
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Application No.: US10499422Application Date: 2002-12-20
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Publication No.: US07919076B2Publication Date: 2011-04-05
- Inventor: Karel Ulbrich , Tomas Etrych , Blanka Rihova , Marketa Jelinkova , Marek Kovar
- Applicant: Karel Ulbrich , Tomas Etrych , Blanka Rihova , Marketa Jelinkova , Marek Kovar
- Applicant Address: CZ
- Assignee: Zentiva, k.s.
- Current Assignee: Zentiva, k.s.
- Current Assignee Address: CZ
- Agency: Morrison & Foerster LLP
- Priority: CZ4653-01 20011220
- International Application: PCT/CZ02/00070 WO 20021220
- International Announcement: WO03/053473 WO 20030703
- Main IPC: A61K31/74
- IPC: A61K31/74
Abstract:
Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of α-amino acids, ε-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated α-amino acids, ε-amino acids, aromatic amino acids or oligopeptides or their sodium salts.
Public/Granted literature
- US20060057099A1 Ph-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy Public/Granted day:2006-03-16
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