Invention Grant
- Patent Title: Anti-glypican 3 antibody
- Patent Title (中): 抗磷脂酰肌醇蛋白聚糖3抗体
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Application No.: US10583795Application Date: 2005-07-08
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Publication No.: US07919086B2Publication Date: 2011-04-05
- Inventor: Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
- Applicant: Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2004-203637 20040709
- International Application: PCT/JP2005/013103 WO 20050708
- International Announcement: WO2006/006693 WO 20060119
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07H21/04 ; C12N5/06 ; C12P21/06
Abstract:
An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
Public/Granted literature
- US07776329B2 Anti-glypican 3 antibody Public/Granted day:2010-08-17
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