Invention Grant
- Patent Title: Soluble and stabilized trimeric form of gp41 polypeptides
- Patent Title (中): 可溶性和稳定的三聚体形式的gp41多肽
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Application No.: US10573704Application Date: 2004-07-29
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Publication No.: US07919100B2Publication Date: 2011-04-05
- Inventor: Sylvain Fleury , Marc P Girard , Marie-Gaëlle Roger , Nicolas Mouz , Pierre-François Serres
- Applicant: Sylvain Fleury , Marc P Girard , Marie-Gaëlle Roger , Nicolas Mouz , Pierre-François Serres
- Applicant Address: US NY New York
- Assignee: Mymetics Corporation
- Current Assignee: Mymetics Corporation
- Current Assignee Address: US NY New York
- Agency: Oliff & Berridge, PLC
- International Application: PCT/IB2004/002433 WO 20040729
- International Announcement: WO2005/010033 WO 20050203
- Main IPC: A61K39/21
- IPC: A61K39/21
Abstract:
The present invention concerns a modified polypeptide containing at least an immunodominant region and the connecting loop between N- and C-helices of gp41 ectodomain of HIV-1, wherein the connecting loop includes at least a linker fragment having: —a size convenient for keeping the native conformation of the interaction between N- and C-helices, and —an hydrophily sufficient to provide a soluble and stable trimeric form to said modified polypeptide.
Public/Granted literature
- US20080213292A1 Soluble And Stabilized Trimeric Form Of Gp41 Polypeptides Public/Granted day:2008-09-04
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