Invention Grant
US07919103B2 Compound and method for regulating plasminogen activation and cell migration
有权
调节纤溶酶原激活和细胞迁移的化合物和方法
- Patent Title: Compound and method for regulating plasminogen activation and cell migration
- Patent Title (中): 调节纤溶酶原激活和细胞迁移的化合物和方法
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Application No.: US10556145Application Date: 2004-05-07
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Publication No.: US07919103B2Publication Date: 2011-04-05
- Inventor: Richard Béliveau , Michel Demeule , Yanick Bertrand , Jonathan Michaud-Levesque , Yannève Rolland , Julie Jodoin
- Applicant: Richard Béliveau , Michel Demeule , Yanick Bertrand , Jonathan Michaud-Levesque , Yannève Rolland , Julie Jodoin
- Applicant Address: CA Montreal
- Assignee: Transfert Plus
- Current Assignee: Transfert Plus
- Current Assignee Address: CA Montreal
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- International Application: PCT/CA2004/000697 WO 20040507
- International Announcement: WO2004/099410 WO 20041118
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38
Abstract:
The invention relates to novel regulators of plasminogen activation and their use for regulating cell migration, plasminolysis, angiogenesis, fibrinolysis, for treating cancer and thrombo-embolic diseases such as heart stroke. Furthermore, the present invention relates to novel pharmaceutical compositions form regulating cell migration, plasminolysis, angiogenesis and for treating cancer. In particular, the present invention relates to a method of regulating the activation of plasminogen comprising contacting a solution of pro-urokinase (uPA) or tissue plasminogen activator (tPA) and plasminogen with melanotransferrin (p97) for a time sufficient to effect regulation thereof.
Public/Granted literature
- US20070053894A1 Compound and method for regulating plasminogen activation and cell migration Public/Granted day:2007-03-08
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