Invention Grant
US07919233B2 Motif of the beclin protein which interacts with anti-apoptotic members of the Bcl-2 protein family, and uses
失效
与Bcl-2蛋白家族的抗凋亡成员相互作用的beclin蛋白的主题和用途
- Patent Title: Motif of the beclin protein which interacts with anti-apoptotic members of the Bcl-2 protein family, and uses
- Patent Title (中): 与Bcl-2蛋白家族的抗凋亡成员相互作用的beclin蛋白的主题和用途
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Application No.: US11883438Application Date: 2006-01-31
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Publication No.: US07919233B2Publication Date: 2011-04-05
- Inventor: Olivier Geneste , John Hickman , Jean-Christophe Rain
- Applicant: Olivier Geneste , John Hickman , Jean-Christophe Rain
- Applicant Address: FR Suresnes Cedex
- Assignee: Les Laboratoires Servier
- Current Assignee: Les Laboratoires Servier
- Current Assignee Address: FR Suresnes Cedex
- Agency: Hueschen and Sage
- Priority: FR0500977 20050201
- International Application: PCT/FR2006/000205 WO 20060131
- International Announcement: WO2006/082303 WO 20060810
- Main IPC: G01N33/574
- IPC: G01N33/574 ; G01N33/53
Abstract:
The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarization. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.
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